| Date | League | Pos | Result | Pos | | xScore | Perf | Home | Away | Wins | Draws | Losses | Points | Pts/Game |
|---|
| 18 Apr | EFL 1 | 19 | Leyton Orient 0 - 2 Rotherham United | 23 |  | 0 - 0  |  | | | 0/1 | 0/1 | 1/1 | 0/3 | 0.0 |
| 11 Apr | EFL 1 | 1 | Lincoln City 2 - 1 Leyton Orient | 15 | | 3 - 1  |  | | | 0/2 | 0/2 | 2/2 | 0/6 | 0.0 |
| 6 Apr | EFL 1 | 15 | Leyton Orient 1 - 2 Huddersfield Town | 10 | | 2 - 1 | | | | 0/3 | 0/3 | 3/3 | 0/9 | 0.0 |
| 2 Apr | EFL 1 | 19 | Wigan Athletic 0 - 0 Leyton Orient | 17 |  | 1 - 1 | | | | 0/4 | 1/4 | 3/4 | 1/12 | 0.3 |
| 28 Mar | EFL 1 | 20 | Exeter City 0 - 0 Leyton Orient | 17 | | 0 - 1 | | | | 0/5 | 2/5 | 3/5 | 2/15 | 0.4 |
| 21 Mar | EFL 1 | 16 | Leyton Orient 2 - 0 Wycombe Wanderers | 9 |  | 2 - 1 |  | | | 1/6 | 2/6 | 3/6 | 5/18 | 0.8 |
| 17 Mar | EFL 1 | 13 | AFC Wimbledon 2 - 4 Leyton Orient | 19 | | 1 - 2 | | | | 2/7 | 2/7 | 3/7 | 8/21 | 1.1 |
| 14 Mar | EFL 1 | 22 | Leyton Orient 2 - 1 Peterborough United | 13 | | 1 - 2 | | | | 3/8 | 2/8 | 3/8 | 11/24 | 1.4 |
| 10 Mar | EFL 1 | 5 | Stevenage 1 - 2 Leyton Orient | 21 | | 2 - 0 | | | | 4/9 | 2/9 | 3/9 | 14/27 | 1.6 |
| 7 Mar | EFL 1 | 5 | Bradford City 2 - 1 Leyton Orient | 22 | | 2 - 1  | | | | 4/10 | 2/10 | 4/10 | 14/30 | 1.4 |
| 28 Feb | EFL 1 | 21 | Leyton Orient 1 - 3 Barnsley | 15 | | 2 - 1 | | | | 4/11 | 2/11 | 5/11 | 14/33 | 1.3 |
| 21 Feb | EFL 1 | 19 | Northampton Town 1 - 2 Leyton Orient | 22 | | 1 - 1 | | | | 5/12 | 2/12 | 5/12 | 17/36 | 1.4 |
| 17 Feb | EFL 1 | 20 | Leyton Orient 1 - 3 Plymouth Argyle | 12 | | 2 - 1 | | | | 5/13 | 2/13 | 6/13 | 17/39 | 1.3 |
| 7 Feb | EFL 1 | 4 | Stockport County 0 - 0 Leyton Orient | 22 | | 2 - 0 | | | | 5/14 | 3/14 | 6/14 | 18/42 | 1.3 |
| 31 Jan | EFL 1 | 20 | Leyton Orient 0 - 1 Port Vale | 24 | | 3 - 1 | | | | 5/15 | 3/15 | 7/15 | 18/45 | 1.2 |
| 27 Jan | EFL 1 | 22 | Doncaster Rovers 3 - 0 Leyton Orient | 19 | | 1 - 1 | | | | 5/16 | 3/16 | 8/16 | 18/48 | 1.1 |
| 24 Jan | EFL 1 | 4 | Bolton Wanderers 2 - 1 Leyton Orient | 18 | | 3 - 1 | | | | 5/17 | 3/17 | 9/17 | 18/51 | 1.1 |
| 17 Jan | EFL 1 | 20 | Leyton Orient 3 - 1 Reading | 12 | | 2 - 1 | | | | 6/18 | 3/18 | 9/18 | 21/54 | 1.2 |
| 10 Jan | EFL 1 | 20 | Leyton Orient 1 - 1 Cardiff City | 1 | | 2 - 2 | | | | 6/19 | 4/19 | 9/19 | 22/57 | 1.2 |
| 1 Jan | EFL 1 | 20 | Leyton Orient 1 - 3 AFC Wimbledon | 15 | | 2 - 1 | | | | 6/20 | 4/20 | 10/20 | 22/60 | 1.1 |
| 29 Dec | EFL 1 | 8 | Luton Town 3 - 0 Leyton Orient | 18 | | 2 - 1 | | | | 6/21 | 4/21 | 11/21 | 22/63 | 1.0 |
| 26 Dec | EFL 1 | 15 | Peterborough United 1 - 0 Leyton Orient | 14 | | 2 - 1  | | | | 6/22 | 4/22 | 12/22 | 22/66 | 1.0 |
| 20 Dec | EFL 1 | 16 | Leyton Orient 2 - 1 Bradford City | 3 | | 2 - 2 | | | | 7/23 | 4/23 | 12/23 | 25/69 | 1.1 |
| 13 Dec | EFL 1 | 10 | Barnsley 3 - 2 Leyton Orient | 15 | | 2 - 1 | | | | 7/24 | 4/24 | 13/24 | 25/72 | 1.0 |
| 9 Dec | EFL 1 | 18 | Leyton Orient 1 - 1 Luton Town | 8 | | 2 - 1 | | | | 7/25 | 5/25 | 13/25 | 26/75 | 1.0 |
| 29 Nov | EFL 1 | 17 | Burton Albion 0 - 4 Leyton Orient | 19 | | 0 - 1 | | | | 8/26 | 5/26 | 13/26 | 29/78 | 1.1 |
| 22 Nov | EFL 1 | 20 | Leyton Orient 1 - 1 Blackpool | 22 | | 3 - 2 | | | | 8/27 | 6/27 | 13/27 | 30/81 | 1.1 |
| 15 Nov | EFL 1 | 21 | Leyton Orient 2 - 1 Exeter City | 15 | | 2 - 0 | | | | 9/28 | 6/28 | 13/28 | 33/84 | 1.2 |
| 8 Nov | EFL 1 | 18 | Wycombe Wanderers 4 - 1 Leyton Orient | 16 | | 2 - 1 | | | | 9/29 | 6/29 | 14/29 | 33/87 | 1.1 |
| 25 Oct | EFL 1 | 16 | Leyton Orient 1 - 0 Lincoln City | 6 | | 2 - 1 | | | | 10/30 | 6/30 | 14/30 | 36/90 | 1.2 |
| 18 Oct | EFL 1 | 22 | Rotherham United 1 - 0 Leyton Orient | 13 | | 2 - 1 | | | | 10/31 | 6/31 | 15/31 | 36/93 | 1.2 |
| 11 Oct | EFL 1 | 18 | Leyton Orient 4 - 0 Doncaster Rovers | 10 | | 1 - 1 | | | | 11/32 | 6/32 | 15/32 | 39/96 | 1.2 |
| 4 Oct | EFL 1 | 4 | Cardiff City 4 - 3 Leyton Orient | 17 | | 3 - 1 | | | | 11/33 | 6/33 | 16/33 | 39/99 | 1.2 |
| 27 Sep | EFL 1 | 14 | Leyton Orient 2 - 3 Stevenage | 2 | | 2 - 2 | | | | 11/34 | 6/34 | 17/34 | 39/102 | 1.1 |
| 20 Sep | EFL 1 | 21 | Reading 2 - 1 Leyton Orient | 14 | | 1 - 1 | | | | 11/35 | 6/35 | 18/35 | 39/105 | 1.1 |
| 13 Sep | EFL 1 | 12 | Leyton Orient 1 - 1 Bolton Wanderers | 10 | | 2 - 1 | | | | 11/36 | 7/36 | 18/36 | 40/108 | 1.1 |
| 6 Sep | EFL 1 | 23 | Port Vale 2 - 3 Leyton Orient | 16 | | 0 - 1 | | | | 12/37 | 7/37 | 18/37 | 43/111 | 1.2 |
| 30 Aug | EFL 1 | 13 | Leyton Orient 0 - 1 Northampton Town | 18 | | 3 - 1 | | | | 12/38 | 7/38 | 19/38 | 43/114 | 1.1 |
| 23 Aug | EFL 1 | 12 | Mansfield Town 4 - 1 Leyton Orient | 9 | | - | | | | 12/39 | 7/39 | 20/39 | 43/117 | 1.1 |
| 19 Aug | EFL 1 | 22 | Plymouth Argyle 0 - 1 Leyton Orient | 14 | | - | | | | 13/40 | 7/40 | 20/40 | 46/120 | 1.2 |
| 16 Aug | EFL 1 | 16 | Leyton Orient 2 - 2 Stockport County | 3 | | 2 - 2 | | | | 13/41 | 8/41 | 20/41 | 47/123 | 1.1 |
| 9 Aug | EFL 1 | 24 | Leyton Orient 2 - 0 Wigan Athletic | 4 | | - | | | | 14/42 | 8/42 | 20/42 | 50/126 | 1.2 |
| 2 Aug | EFL 1 | - | Huddersfield Town 3 - 0 Leyton Orient | - | | - | - | | | 14/43 | 8/43 | 21/43 | 50/129 | 1.2 |